Neuroscience
18 April 2024
J Neuroinflammation. 2024 Apr 17;21(1):98. doi: 10.1186/s12974-024-03098-4.
ABSTRACT
BACKGROUND: Traumatic brain injury (TBI) is associated with the development of visual system disorders. Visual deficits can present with delay and worsen over time, and may be associated with an ongoing neuroinflammatory response that is known to occur after TBI. Complement system activation is strongly associated with the neuroinflammatory response after TBI, but whether it contributes to vision loss after TBI is unexplored.
METHODS: Acute and chronic neuroinflammatory changes within the dorsal lateral geniculate nucleus (dLGN) and retina were investigated subsequent to a moderate to severe murine unilateral controlled cortical impact. Neuroinflammatory and histopathological outcomes were interpreted in the context of behavioral and visual function data. To investigate the role of complement, cohorts were treated after TBI with the complement inhibitor, CR2-Crry.
RESULTS: At 3 days after TBI, complement component C3 was deposited on retinogeniculate synapses in the dLGN both ipsilateral and contralateral to the lesion, which was reduced in CR2-Crry treated animals. This was associated with microglia morphological changes in both the ipsilateral and contralateral dLGN, with a less ramified phenotype in vehicle compared to CR2-Crry treated animals. Microglia in vehicle treated animals also had a greater internalized VGlut2 + synaptic volume after TBI compared to CR2-Crry treated animals. Microglia morphological changes seen acutely persisted for at least 49 days after injury. Complement inhibition also reduced microglial synaptic internalization in the contralateral dLGN and increased the association between VGLUT2 and PSD95 puncta, indicating preservation of intact synapses. Unexpectedly, there were no changes in the thickness of the inner retina, retinal nerve fiber layer or retinal ganglion layer. Neuropathological changes in the dLGN were accompanied by reduced visual acuity at subacute and chronic time points after TBI, with improvement seen in CR2-Crry treated animals.
CONCLUSION: TBI induces complement activation within the dLGN and promotes microglial activation and synaptic internalization. Complement inhibition after TBI in a clinically relevant paradigm reduces complement activation, maintains a more surveillance-like microglia phenotype, and preserves synaptic density within the dLGN. Together, the data indicate that complement plays a key role in the development of visual deficits after TBI via complement-dependent microglial phagocytosis of synapses within the dLGN.
PMID:38632569 | DOI:10.1186/s12974-024-03098-4
Add to Google Keep
See Also
DHA’s TBI-focused Caregiver & Family Member Study continues at TBICoEUniversity of Michigan Medical School ResearchPRIME PubMed | Measuring patient outcomes in chronic heart failure: psychometric properties of the Care-Related Quality of Life survey for Chronic Heart Failure (CaReQoL CHF)PRIME PubMed | CHF-PROM: validation of a patient-reported outcome measure for patients with chronic heart failureShare on Linkedin
Estimated reading time: 7 minute(s)
- Preclinical translational platform of neuroinflammatory disease biology relevant to neurodegenerative disease
- Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
- Bi-directional neuro-immune dysfunction after chronic experimental brain injury
- Multimodal evaluation of the effects of low-intensity ultrasound on cerebral blood flow after traumatic brain injury in mice
- Neutrophil Targeting Platform Reduces Neutrophil Extracellular Traps for Improved Traumatic Brain Injury and Stroke Theranostics
- The combination treatment of hypothermia and intranasal insulin ameliorates the structural and functional changes in a rat model of traumatic brain injury
- Lifelong Chronic Sleep Disruption in a Mouse Model of Traumatic Brain Injury
- Traumatic Brain Injury in Mice Generates Early-Stage Alzheimer's Disease Related Protein Pathology that Correlates with Neurobehavioral Deficits
- Interaction of Alzheimer Disease and Traumatic Brain Injury on Cortical Thickness
- Impact of dementia and socioeconomic disadvantage on days at home after traumatic brain injury among older Medicare beneficiaries: A cohort study
- A meta-analysis of cognitive and functional outcomes in severe brain trauma cases
- E2F1 Mediates Traumatic Brain Injury and Regulates BDNF-AS to Promote the Progression of Alzheimer's Disease
- E2F1 Mediates Traumatic Brain Injury and Regulates BDNF-AS to Promote the Progression of Alzheimer's Disease
- Differences between parent- and teacher-reported executive functioning behaviors after traumatic injuries
- Lesion Frequency Distribution Maps of Traumatic Axonal Injury on Early Magnetic Resonance Imaging after Moderate and Severe Traumatic Brain Injury and Associations to 12 Months Outcome
- Delineating the impact of childhood traumatic brain injury (TBI) on long-term depressive symptom severity: Does sub-acute brain morphometry prospectively predict 2-year outcome?
- Temporal and structural sensitivities of major biomarkers for detecting neuropathology after traumatic brain injury in the mouse
- Medication utilization in traumatic brain injury patients-insights from a population-based matched cohort study
- Contrasting Characteristics and Outcomes of Sports-Related and Non-Sports-Related Traumatic Brain Injury
- Traumatic Brain Injury and Post-Traumatic Stress Disorder and Their Influence on Development and Pattern of Alzheimer's Disease Pathology in Later Life
- The Influence of the Family Functioning and Social Relationships on Child Participation After Traumatic Brain Injury
- Electroacupuncture Inhibits Neural Ferroptosis in Rat Model of Traumatic Brain Injury via Activating System Xc-/GSH/GPX4 Axis
- Utility of in-session assessments during cognitive behavioral therapy for depression after traumatic brain injury: Results from arandomized controlled trial
- dTBI2: A Calibrated, Tunable Device for Administering Traumatic Brain Injury in Drosophila
- Harmonizing federal interagency traumatic brain injury research data to examine depression and suicide-related outcomes
- Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury
- Role of NLRP3 inflammasome in prevention and treatment of cognitive impairment-related diseases and traditional Chinese medicine intervention: a review
- Disparities between Native Americans and Whites in trajectories of functional independence and life satisfaction over the 5 years after traumatic brain injury
- The relationship between HIV-1 neuroinflammation, neurocognitive impairment and encephalitis pathology: A systematic review of studies investigating post-mortem brain tissue
- Comorbid treatment of traumatic brain injury and mental health disorders
- Women Report Worse Neurobehavioral Symptoms than Men following Mild Traumatic Brain Injury in U.S. Military Service Members
- Traumatic Brain Injury, Psychological Trauma Exposure, and Anxious and Depressive Symptoms in a Clinical Population
- Epidemiology of moderate traumatic brain injury and factors associated with poor neurological outcome
- Hypoxia inducible factor-1α regulates microglial innate immune memory and the pathology of Parkinson's disease
- The economic impact of cannabis use disorder and dementia diagnosis in veterans diagnosed with traumatic brain injury
- Healthcare perceptions of persons with traumatic brain injuries across providers: shortcomings in the chronic phase of care
- The Contribution of Microglia and Brain-Infiltrating Macrophages to the Pathogenesis of Neuroinflammatory and Neurodegenerative Diseases during TMEV Infection of the Central Nervous System
- Mild traumatic brain injury, PTSD symptom severity, and behavioral dyscontrol: a LIMBIC-CENC study
- Healthy Days at Home Among Older Medicare Beneficiaries With Traumatic Brain Injury Requiring Inpatient Rehabilitation
- Chondroitin sulfate proteoglycans mRNA expression and degradation in the zebra finch following traumatic brain injury
- Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias
- Decreased uncinate fasciculus integrity in functional seizures following traumatic brain injury
- Sleep Disturbance during Post-Traumatic Amnesia and Early Recovery following Traumatic Brain Injury
- Blood-brain barrier disruption following brain injury: Implications for clinical practice
- Ketamine's mechanism of action with an emphasis on neuroimmune regulation: can the complement system complement ketamine's antidepressant effects?
- Sex Differences in Sleep Architecture After Traumatic Brain Injury: Potential Implications on Short-Term Episodic Memory and Recovery
- Impact of PTSD treatment on postconcussive symptoms in veterans: A comparison of sertraline, prolonged exposure, and their combination
- Virus-induced brain pathology and the neuroinflammation-inflammation continuum: the neurochemists view
- Galectin-3 Plays a Role in Neuroinflammation in the Visual Pathway in Experimental Optic Neuritis
- Galectin-3 Plays a Role in Neuroinflammation in the Visual Pathway in Experimental Optic Neuritis
- STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke
- The Effectiveness of Brain Injury Family Intervention in Improving the Psychological Well-Being of Caregivers of Patients With Traumatic Brain Injury: Protocol for a Randomized Controlled Trial
- Temporal sensitivity for achromatic and chromatic flicker across the visual cortex
- Machine learning prediction models for in-hospital postoperative functional outcome after moderate-to-severe traumatic brain injury
- The complement system in neurodegenerative diseases
- CSF β-Amyloid and Tau Biomarker Changes in Veterans With Mild Traumatic Brain Injury
- Recent insights from non-mammalian models of brain injuries: an emerging literature
- Effectiveness of biomedical interventions on the chronic stage of traumatic brain injury: a systematic review of randomized controlled trials
- Long-term impact of maternal obesity on the gliovascular unit and ephrin signaling in the hippocampus of adult offspring
- Cognitive behavioral therapy for managing depressive and anxiety symptoms after brain injury: a meta-analysis
- Traumatic brain injury in patients over 65 years of age attended in the emergency department, characteristics and complications
- Association of mild traumatic brain injury, post-traumatic stress disorder, and other comorbidities on photosensitivity
- Visual, perceptual functions, and functional vision in children with unilateral cerebral palsy compared to children with neurotypical development
- Visual, perceptual functions, and functional vision in children with unilateral cerebral palsy compared to children with neurotypical development
(recent articles with at least 5 words in title)
- Preclinical translational platform of neuroinflammatory disease biology relevant to neurodegenerative disease
- Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model
- Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation
- Traumatic Brain Injury and Opioids: Twin Plagues of the Twenty-First Century
- Bi-directional neuro-immune dysfunction after chronic experimental brain injury
- Multimodal evaluation of the effects of low-intensity ultrasound on cerebral blood flow after traumatic brain injury in mice
- Loss of Consciousness and Righting Reflex Following Traumatic Brain Injury: Predictors of Post-Injury Symptom Development (A Narrative Review)
- Neutrophil Targeting Platform Reduces Neutrophil Extracellular Traps for Improved Traumatic Brain Injury and Stroke Theranostics
- The combination treatment of hypothermia and intranasal insulin ameliorates the structural and functional changes in a rat model of traumatic brain injury
- Lifelong Chronic Sleep Disruption in a Mouse Model of Traumatic Brain Injury
- Traumatic Brain Injury in Mice Generates Early-Stage Alzheimer's Disease Related Protein Pathology that Correlates with Neurobehavioral Deficits
- Single Versus Repetitive Traumatic Brain Injury: Current Knowledge on the Chronic Outcomes, Neuropathology and the Role of TDP-43 Proteinopathy
- Interaction of Alzheimer Disease and Traumatic Brain Injury on Cortical Thickness
- Multiplexed Quantitative Proteomics Reveals Proteomic Alterations in Two Rodent Traumatic Brain Injury Models
- Moral Injury is a Risk Factor for Substance Use and Suicidality Among US Military Veterans with and withoutTraumatic Brain Injury
- Is lifetime traumatic brain injury a risk factor for mild cognitive impairment in veterans compared to non-veterans?
- Optimization of a translational murine model of closed-head traumatic brain injury
- Myricetin suppresses traumatic brain injury-induced inflammatory response via EGFR/AKT/STAT pathway
- Associations of Enlarged Perivascular Spaces With Brain Lesions, Brain Age, and Clinical Outcomes in Chronic Traumatic Brain Injury
- Activation of GPER-1 Attenuates Traumatic Brain Injury-Induced Neurological Impairments in Mice
- Neurotrophins and neural stem cells in posttraumatic brain injury repair
- Phenotyping Depression after Mild Traumatic Brain Injury: Evaluating the Impact of Multiple Injury, Gender, and Injury Context
- The prevalence of persistent post-traumatic headache in adult civilian traumatic brain injury: a systematic review and meta-analysis on the past 14 years
- Impact of dementia and socioeconomic disadvantage on days at home after traumatic brain injury among older Medicare beneficiaries: A cohort study
- Astrogliosis marker 11C-SL2511.88 PET in traumatic brain injury with persistent symptoms
- The reliability and validity of the TBI-CareQOL system in four diverse caregiver groups
- Traumatic Brain Injury and Long-Term Risk of Stroke Among US Military Veterans
- Blood-Based Biomarkers in Traumatic Brain Injury: A Narrative Review With Implications for the Legal System
- HDAC inhibitor attenuates rat traumatic brain injury induced neurological impairments
- A meta-analysis of cognitive and functional outcomes in severe brain trauma cases
- Neuroanatomical zones of human traumatic brain injury reveal significant differences in protein profile and protein oxidation: Implications for secondary injury events
- Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury
- A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury
- Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Veteran Men - A Twin Study
- E2F1 Mediates Traumatic Brain Injury and Regulates BDNF-AS to Promote the Progression of Alzheimer's Disease
- E2F1 Mediates Traumatic Brain Injury and Regulates BDNF-AS to Promote the Progression of Alzheimer's Disease
- Biomarker-guided neuromodulation aids memory in traumatic brain injury
- Identifying the Phenotypes of Diffuse Axonal Injury Following Traumatic Brain Injury
- Application of P7C3 Compounds to Investigating and Treating Acute and Chronic Traumatic Brain Injury
- Inhibition of the interaction between microglial adenosine 2A receptor and NLRP3 inflammasome attenuates neuroinflammation posttraumatic brain injury
- Coverage of education and training of traumatic brain injury-induced growth hormone deficiency in US residency and fellowship programs: a cross-sectional study
- Evaluating the effect of post-traumatic hypoxia on the development of axonal injury following traumatic brain injury in sheep
- Characterization of Traumatic Brain Injury in a Gyrencephalic Ferret Model Using the Novel Closed Head Injury Model of Engineered Rotational Acceleration (CHIMERA)
- Association of Traumatic Brain Injury with Late Life Neuropathological Outcomes in a Community-Based Cohort
- Evaluating the neuroprotective effects of progesterone receptors on experimental traumatic brain injury: The PI3K/Akt pathway
- Differences between parent- and teacher-reported executive functioning behaviors after traumatic injuries
- Lesion Frequency Distribution Maps of Traumatic Axonal Injury on Early Magnetic Resonance Imaging after Moderate and Severe Traumatic Brain Injury and Associations to 12 Months Outcome
- Augmented feedback modes during functional grasp training with an intelligent glove and virtual reality for persons with traumatic brain injury
- Head Kinematics, Blood Biomarkers and Histology in Large Animal Models of Traumatic Brain Injury and Hemorrhagic Shock
- Delineating the impact of childhood traumatic brain injury (TBI) on long-term depressive symptom severity: Does sub-acute brain morphometry prospectively predict 2-year outcome?
- Precision functional MRI mapping reveals distinct connectivity patterns for depression associated with traumatic brain injury
- Obsessive-compulsive disorder following severe traumatic brain injury
- The dorsal lateral geniculate nucleus and the pulvinar as essential partners for visual cortical functions
- HEalth And Dementia outcomes following Traumatic Brain Injury (HEAD-TBI): protocol for a retrospective cohort study
- Uqcr11 alleviates oxidative stress and apoptosis after traumatic brain injury
- Temporal and structural sensitivities of major biomarkers for detecting neuropathology after traumatic brain injury in the mouse
- Physicians' beliefs and perceived importance of traumatic brain injury-associated agitation in critically ill patients: a survey of Canadian intensivists
- Associations between peer relationships and self-esteem after childhood traumatic brain injury: exploring the mediating role of loneliness
- Medication utilization in traumatic brain injury patients-insights from a population-based matched cohort study
- Research Letter: TBI Severity Moderates the Association Between Subjective and Objective Attention in Older Veterans
- Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury
- Contrasting Characteristics and Outcomes of Sports-Related and Non-Sports-Related Traumatic Brain Injury
- Traumatic Brain Injury and Post-Traumatic Stress Disorder and Their Influence on Development and Pattern of Alzheimer's Disease Pathology in Later Life
- The Purple Heart and suicide risk in Post-9/11 U.S. Army Combat Veterans with a traumatic brain injury: A mixed methods study
Inneuroscience
New Evidence
19 April 2024
Circuit-wide gene network analysis reveals sex-specific roles for phosphodiesterase 1b in cocaine addiction
J Neurosci. 2024 Apr 18:e1327232024. doi: 10.1523/JNEUROSCI.1327-23.2024. Online ahead of print.ABSTRACTCocaine use disorder is a significant public health issue without an effective pharmacological treatment. Successful...
19 April 2024
Pregnancy outcomes of Fabry disease in Austria (PROFABIA)-a retrospective cohort-study
Orphanet J Rare Dis. 2024 Apr 18;19(1):165. doi: 10.1186/s13023-024-03180-3.ABSTRACTBACKGROUND: Pregnancy and delivery outcomes in women with Fabry disease are not well described.METHODS: Retrospective cohort-study of...
19 April 2024
Reducing anti-fat bias toward the self and others: a randomized controlled trial
J Eat Disord. 2024 Apr 18;12(1):46. doi: 10.1186/s40337-024-00994-1.ABSTRACTDespite strong evidence linking anti-fat bias directed toward others with markers of self-directed anti-fat bias, there is a...
19 April 2024
Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry
Ital J Pediatr. 2024 Apr 18;50(1):73. doi: 10.1186/s13052-024-01644-7.ABSTRACTBACKGROUND: In response to the imperative need for standardized support for adolescent Gender Dysphoria (GD), the Italian Academy...
19 April 2024
Evaluating the prevalence and risk factors for depression in patients with temporal lobe epilepsy with hippocampal sclerosis: A cross-sectional multicenter study
Epilepsy Behav. 2024 Apr 17;154:109782. doi: 10.1016/j.yebeh.2024.109782. Online ahead of print.ABSTRACTBACKGROUND: Epilepsy frequently accompanies Major Depressive Disorder (MDD). Notably, people with temporal lobe epilepsy and...
19 April 2024
It’s OK to move! Effect of a brief video on community confidence in activity despite back pain: A randomised trial
J Orthop Sports Phys Ther. 2024 Apr 18:1-26. doi: 10.2519/jospt.2024.12412. Online ahead of print.ABSTRACTOBJECTIVE: To estimate the difference in confidence to become active despite low...
